Our Technology
A world-class synthesis and analytical platform built on 15 years of continuous investment in scientific excellence.
Solid-Phase Peptide Synthesis at Every Scale
Our synthesis platform is built around automated Fmoc-SPPS as the primary methodology, with Boc-SPPS available for sequences requiring orthogonal protecting group strategies.
We operate 12 automated peptide synthesisers ranging from small-scale parallel synthesis (96-well format, mg quantities) to large-scale batch reactors capable of multi-kilogram GMP production. All synthesisers are qualified and operated under cGMP conditions when required.
- Fmoc and Boc SPPS on Wang, Rink Amide, and Sieber resin supports
- Parallel synthesis capability: up to 96 sequences simultaneously
- Scale range: 1 mg to multi-kilogram batches
- Microwave-assisted synthesis for difficult sequences
- Native chemical ligation for proteins >50 amino acids
Analytical Infrastructure
Preparative HPLC
Eight preparative HPLC systems (C18 and C8 columns) for single-pass purification of crude peptides to target purity specifications from 85% to >99%. Batch sizes from 100 mg to 2 kg per run.
Mass Spectrometry
ESI-MS (single quadrupole and triple quadrupole), MALDI-TOF, and LC-MS/MS for comprehensive sequence confirmation and impurity profiling. Every peptide shipment includes a mass spec certificate.
Amino Acid Analysis
Hydrolysis-based amino acid analysis (AAA) for accurate quantification of peptide content and composition verification, critical for GMP certificates of analysis.
Lyophilisation
Industrial-scale freeze-drying facilities for conversion of HPLC-purified peptide solutions to stable, water-free lyophilised powders optimised for long-term storage and shipping.
NMR Spectroscopy
400 MHz and 600 MHz NMR spectrometers for structural confirmation of modified peptides, cyclic peptides, and novel peptidomimetic structures where MS alone is insufficient.
Cold-Chain Storage
Dedicated −80°C ultra-cold storage for sensitive peptides and working stock repositories. Validated packaging for shipping at 2–8°C or on dry ice to any global destination.
GMP Manufacturing for Pharmaceutical Clients
Our Boston facility includes four dedicated GMP manufacturing suites operating under ICH Q7 guidelines. All GMP batches are manufactured under full documentation control with electronic batch records, equipment qualification (IQ/OQ/PQ), and change control procedures.
We produce peptide APIs for Phase I through Phase III clinical trials and have supported multiple IND submissions for US FDA and EMA regulatory programmes.
View Quality ControlICH Q7 GMP Compliant
Full ICH Q7 GMP compliance for APIs used in clinical trials. Regulatory support for FDA, EMA, PMDA submissions.
Clinical to Commercial Scale
Seamless scale-up from Phase I (gram quantities) to commercial (kilogram) batches with validated technology transfer protocols.
Full Regulatory Package
DMF filings, CoA, Certificate of Origin, method validation reports, and stability data provided as standard.